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When they asked the nation’s trial lawyers: ‘What’s your favorite legal thriller?’ there was a surprise.

In the September 2017 edition of Trial Magazine, they asked the nation’s trial lawyers “what’s your favorite legal thriller?”

To have Taming the Telomeres mentioned in a favorite legal thriller list with Greg Iles and Truman Capote, well, is pretty humbling and amazing.  Thank you Wayne Parsons of Hawaii!

Taming the Telomeres won the Gold Award in the Reader’s Favorite 2015 Literary Award Contest for suspense thriller, and later, during May 2016,  the novel held the #1 thriller position on Amazon for suspense thriller ebook.  The author is working on a follow along sequel to the novel, and re-posts a sneak preview of the Prologue chapter for the forthcoming novel, tentatively titled Targeting the Telomeres.

Sleeper

What kind of scum-sucking cockroaches kidnap a defenseless baby, Amanda Michaels thinks while trying to fall asleep. She will make them regret that decision.

Lying on the cramped, lower bunk of the sleeper car, she feels with her fingertips along the thin foam-rubber pad masquerading as a mattress. There it is. She tugs on the lower portion of her backpack hiding the loaded pistol with the customized silencer, nestling what constitutes all her belongings in the crook of her right arm. The sheath strapped under the left pant leg of her jeans secures a long KA-Bar serrated edge fixed blade knife. And in the right pocket of her hoodie are two identical burner cell phones. One is her only means of communication with her compatriot, who is also on the train, both of them full-in with their improbable mission. Imagining the linen scent of her favorite candle briefly tricks her olfactory glands into ignoring the foul odors. The elderly Chinese lady on the bunk overhead smells of mildewing clothes. On the lower bunk an arm’s length away, a twenty-something Chinese girl sleeps with her jacket over her head. The sleeper car’s other occupant, a tiny woman who barely stands five-foot tall and can’t weigh 100 pounds, presses her torso against the tiny sink, paper towels surrounding the collar of her shirt, while she works some type of soapy liquid through her dark brown shoulder-length hair. Amanda decides to pass on that shower.

She thinks, all I wanted was to get some of my memory back from before the crash. Not this.

If she’s captured, what could Chinese intelligence agents possibly “get” out of her anyhow? Sure, she survived the Hemispheres plane crash, but she doesn’t know how or why. Only that it might have had something to do with her dad’s research and her being his test subject. To study her telomeres, maybe that’s what they would want? Most likely to torture her to learn whatever she knows.

The bullet train hurtling northbound towards Beijing at 180 miles per hour suddenly lurches, causing a metallic screech that soon fades.

Amanda thinks for a moment about a family photo. Of her dad, her, and her mom, sitting on the front porch of the house they lived in before the crash. The one she hopes to recall, that her Uncle Andy showed her. She mentally photoshops her baby brother Justin in too. Nothing can stop fantasies no one else can see.

The sink-showering lady climbs back up to her top bunk, and talks in Chinese with the other older lady.

If my plan fails, I won’t have to worry anymore, Amanda decides. Because I’ll be dead.

(c) 2017 R.N. Shapiro All Rights Reserved.

 

Telomere Breakthroughs Hold Key To Aging, Cancer & Human Life Extension

A powerful subplot of my award winning fiction thriller Taming the Telomeres deals with DNA telomere research and its impact on human aging, and the possible extension of human life. TTT explores tragedy that befalls Amanda Michaels, and how she discovers that secret telomere research her biological father Ron Michaels was exploring had attracted the interest of the world’s most powerful nations. Amanda hunts for answers in the midst of spying, subterfuge, and nation’s seeking economic leverage over the telomere research.

Blackburn talk

As many of you may be aware, in 2009 three scientists shared a Nobel Prize for research on our DNA telomeres and the impact of telomerase enzyme on our cells. With regard to telomere research, readers of my first novel have commented in various ways:

“There wasn’t enough science about telomeres.”

“I didn’t understand the science, that bogged me down.”

“R.N. Shapiro wasn’t even accurate about the science.”

Lot’s of conflicting feedback.  Not enough science.  Too much science.  If you had never heard of a telomere before you saw the title of my first novel, believe me you were not alone. Almost no one except geneticists or biological researchers had ever heard of one either. And when you deal with cutting edge science in a fiction thriller, it’s hard to please everyone all the time.

While it’s important to build a foundation on real science and medicine, fiction by definition may involve a leap of faith, something that might not be grounded 100% in science. Some people call that science fiction. Like getting dinosaur DNA out of petrified amber. There’s a kernel of possibility, but a leap of faith may be necessary.

Most parts of the telomere passages in my first novel was based on real science, but I will admit not all of Amanda’s special characteristics are scientifically based. And how will the telomere elixir she was transfused with impact Amanda in the future? Hmm.

I’m currently researching and writing a follow along sequel to Taming the Telomeres, with the working title “Targeting the Telomeres.” Amanda Michaels, Andy Michaels, and several other characters in the first book are involved in the sequel, which begins less than a year after the end of the first telomeres novel. Along with many new characters. Now, in the midst of writing the second telomeres/Amanda Michaels novel, there have been a number of important genetic research announcements involving telomeres and telomerase enzyme since 2009. And yes these worldwide announcements and discoveries that impact human aging have been exciting.

So what telomere discoveries have been achieved since the 2009 Nobel Prize announcement?

Cancer:  One breakthrough involves telomerase enzyme in cancer cells. Cancer cell telomeres get very short, but the abnormal, damaged cancer cells somehow escape cell death by continually making more telomerase enzyme. Medical researchers are making strides in cutting off the telomerase enzyme in breast and prostate cancer cells to make them die rather than continually reproducing and causing the spread of abnormal cancer tumor cells. But one resultant problem with blocking telomerase enzyme production is that the same elimination can impair fertility, wound healing and production of blood and immune system cells.

Telo blog

Shorter Telomeres=Shorter Lives: In other studies, scientists have shown that shorter telomeres are associated with shorter human lives. In persons over 60, shorter telomeres meant they were three times more likely to die from heart and other infectious diseases than persons with longer telomeres. Even people with longer telomeres after age 60 still experience telomere shortening as they age but noted geneticist Richard Cawthon believes that 10 to 30 years could be added to human life by lengthening our telomeres. Dr. Cawthon says that if all processes of aging could be eliminated and oxidative stress damage could be repaired, one estimate is that the human body could live 1000 years.

Increases in Mice Median Lifespan: By late 2010, Harvard genetic researchers showed that telomerase enzyme in mice genes reversed aging and degenerative processes in the mice. A later 2012 telomere study on laboratory mice increased their median lifespans between 13% and 24% with telomere manipulation. And a genetic study just announced during 2016 from Spain showed that embryonic stem cells with hyper-long telomeres can give rise to organisms (here, mice) with longer telomeres that remain young at the molecular level far longer. Meaning that the longer telomere in stem cells can divide and divide, and the mouse’s cell telomeres become longer. The Spanish scientists are now researching the natural additional question: can they show extension of mice median lifespan based on the hyper-long telomeres?

Human Lifespan Extension: Are scientists inching closer to effectively providing the fountain of youth for our human cells? Perhaps. How many years will it take to roll out medications that will materially extend human life expectancy? No one can yet say.

TTT

Back to my second novel, Targeting the Telomeres, which is still a work in progress. On the telomere front, USA biological researchers will address how to effectively use and deliver telomerase enzyme to lengthen the telomeres in human cells, in more than one way. Powerful competing international “interests” will engage in efforts to gain access to this classified biological genetic research, but in the midst of this, the Michaels family suffers a new family crisis. That’s as far as I can go at this time, but rest assured that much of the telomere science in the second novel will have a solid foundation in recent telomere discoveries.

Thanks to Taming Readers: #1 Suspense Action Thriller on Amazon

Just want to say “wow” and “thank you” to every reader of Taming the Telomeres, as the novel about Amanda Michaels, and her tale of survival and redemption, held the #1 position on Amazon’s best seller charts in the suspense action thriller category in early May.

Taming the Telomeres is now available in ebook, paperback or audiobook on Audible.com and on iTunes.

Working hard on the sequel with the working title ‘Targeting the Telomeres’ which will pickup within a year of where TTT leaves off.

 

Amazon-1

Author Insights on “Air Disaster” chapter from Award Winning Thriller: Taming the Telomeres

This discussion is about the moments when Andy Michaels first learns his close family members were on a Hemispheres jet that crashed in PA. Click here to read the full interactive bublish.com chapter discussions.

air disaster

What’s a Telomere?

telomere imageEvery chromosome has a special ending or cap called a telomere.  It’s like the plastic tip protecting the end of a shoelace.  When a cell divides, some of the telomere is lost.   But some enzymes can cause cell telomeres to have more cell divisions, extending cell life. Sound Intriguing? Read Taming the Telomeres to find out just how valuable telomere biological research is.

 

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